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PKC activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined.

Increasing emergency department visits for anaphylaxis in very early childhood: A canary in the coal mine

The incidence of anaphylaxis is increasing globally in tandem with changing environmental and lifestyle factors. There is very limited data on very early childhood presentations. We aim to assess changes in rates, characteristics and management of infant anaphylaxis in a paediatric ED over a 15-year period.

A Family's Journey at JHC: Analyses of routinely collected data

Desiree Silva MBBS, FRACP, MPH, PhD Co-Director, ORIGINS desiree.silva@thekids.org.au Co-Head, The ORIGINS Project Professor Desiree Silva is

ADAPTS: Antibiotic Dysbiosis And Probiotics Trial in infantS

Desiree Peter Silva Richmond MBBS, FRACP, MPH, PhD MBBS MRCP(UK) FRACP Co-Director, ORIGINS Head, Vaccine Trials Group desiree.silva@thekids.org.au

Bugging allergy; role of pre-, pro- and synbiotics in allergy prevention

Here, we summarize and discuss findings of randomized clinical trials that have examined the effects of these strategies on short and long-term.

Each meal matters in the exposome: Biological and community considerations in fast-food-socioeconomic associations

As we discuss, equal weekly visits to major fast-food outlets by the affluent and deprived do not translate into biological equivalency.

Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles? An exploratory study

Overall results of this preliminary study suggest that supplementation with fish oil may only significantly increase DHA in minor allele carriers of FADS1 SNPs. Further research is required to confirm this novel finding.

Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles?

Supplementation with fish oil may only significantly increase DHA in minor allele carriers of FADS1 SNPs

Study Protocol for a Randomised Controlled Trial Investigating the Effects of Maternal Prebiotic Fibre Dietary Supplementation from Mid-Pregnancy to Six Months’ Post-Partum on Child Allergic Disease Outcomes

Infant allergy is the most common early manifestation of an increasing propensity for inflammation and immune dysregulation in modern environments. Refined low-fibre diets are a major risk for inflammatory diseases through adverse effects on the composition and function of gut microbiota. This has focused attention on the potential of prebiotic dietary fibres to favourably change gut microbiota, for local and systemic anti-inflammatory effects.

Nature Connection: Providing a Pathway from Personal to Planetary Health

The vast and growing challenges for human health and all life on Earth require urgent and deep structural changes to the way in which we live. Broken relationships with nature are at the core of both the modern health crisis and the erosion of planetary health. A declining connection to nature has been implicated in the exploitative attitudes that underpin the degradation of both physical and social environments and almost all aspects of personal physical, mental, and spiritual health.