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This study will identify the incidence of true Group A Streptococcal pharyngitis and serological responses to Group A Streptococcal GAS skin infections

The young age of the first infection with skin sores and scabies reflects the high disease burden in these communities

Group A Streptococcus (GAS) or Streptococcus pyogenes is responsible for an estimated 500,000 deaths worldwide each year.

We propose that hydroxychloroquine could be repurposed to reduce the risk of rheumatic heart disease after acute rheumatic fever

The rates of RHD in Timor-Leste are among the highest in the world, and prevalence is higher among girls than boys

The authors present a variety of pressing clinical research questions on optimal RHD prevention and advanced care

Quantification of the disease burden caused by different risks informs prevention by providing an account of health loss different to that provided by a...

This review outlines a clinical development strategy detailing the phases of development required for registration of a candidate Group A streptococci vaccin

Echocardiographic screening for rheumatic heart disease is cost-effective in our context

Rheumatic heart disease (RHD) after group A streptococcus (GAS) infections is heritable and prevalent in Indigenous populations. Molecular mimicry between human and GAS proteins triggers proinflammatory cardiac valve-reactive T cells.