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Research
Examining relationships between vitamin D over the first decade of life and development of asthma and allergyThis study shows for the first time the importance of considering vitamin D levels over a prolonged period during childhood, rather than at just one or two ages
Research
Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthmaOne of the strongest risk factors for asthma is having chest infections during infancy that are so severe that they trigger symptoms of fever & wheeze
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Respiratory infection- and asthma-prone, low vaccine responder children demonstrate distinct mononuclear cell DNA methylation pathwaysnfants with frequent viral and bacterial respiratory infections exhibit compromised immunity to routine immunizations. They are also more likely to develop chronic respiratory diseases in later childhood. This study investigated the feasibility of epigenetic profiling to reveal endotype-specific molecular pathways with potential for early identification and immuno-modulation.
The Children's Lung Health Team investigates lung growth and development through infancy, childhood, adolescence and early adulthood, in health and in chronic lung disease, and the impact of preterm birth on lung health outcomes.
Research
Global change, climate change, and asthma in children: Direct and indirect effects - A WAO Pediatric Asthma Committee ReportThe twenty-first century has seen a fundamental shift in disease epidemiology with anthropogenic environmental change emerging as the likely dominant factor affecting the distribution and severity of current and future human disease. This is especially true of allergic diseases and asthma with their intimate relationship with the natural environment.
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Real world effectiveness of early ensitrelvir treatment in patients with SARS-CoV-2, a retrospective case seriesEnsitrelvir, a 3C-like protease inhibitor, received emergency approval in Japan in November 2022 for treating non-hospitalized patients with mild-to-moderate COVID-19. However, confirmation of its real-world clinical effectiveness is limited.
The Respiratory Environmental Health team conducts research in early life determinants of lung growth and development, respiratory environmental health, and mechanisms of airway dysfunction in asthma and other respiratory disease.
Research
Hypoallergenic der p 1/Der p 2 combination vaccines for immunotherapy of house dust mite allergyMore than 50% of allergic patients have house dust mite (HDM) allergy.
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Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo modelsThis paper is a review of potential novel therapeutic targets or tools for the treatment of asthma and COPD.
Research
Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthmaThe anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway...