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Insights into respiratory disease through bioinformaticsHere, we review the basic concepts in bioinformatics and genomic data analysis and illustrate the application of these tools to further our understanding of lung diseases
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Prevention of Allergy/Asthma - New StrategiesThis review focuses on the scientific rationale for early intervention aimed at asthma prophylaxis and discusses therapeutic approaches
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Identification of epithelial phospholipase A2 receptor 1 as a potential target in asthmaPLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation
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Differential gene network analysis for the identification of asthma-associated therapeutic targets in allergen-specific T-helper memory responsesDifferential network analysis of allergen-induced CD4 T cell responses can unmask covert disease-associated genes and pin point novel therapeutic targets
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The genetic and epigenetic landscapes of the epithelium in asthmaGenetic factors in airway epithelial cells that are functionally associated with asthma pathogenesis
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Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lungWe aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses
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Probiotics for treatment and primary prevention of allergic diseases and asthma: looking back and moving forwardReview treatment and primary prevention studies, recent meta-analyses, and discuss the current understanding of the role of probiotics in this context
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Thoracic Society of Australia and New Zealand (TSANZ) position statement on chronic suppurative lung disease and bronchiectasis in children, adolescents and adults in Australia and New ZealandThis position statement, updated from the 2015 guidelines for managing Australian and New Zealand children/adolescents and adults with chronic suppurative lung disease (CSLD) and bronchiectasis, resulted from systematic literature searches by a multi-disciplinary team that included consumers.
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Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental AllergyThe pathogenesis of asthma continues to be a major topic of interest to our authors with reviews and original papers on the role of viruses, mechanisms of...
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Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo modelsThis paper is a review of potential novel therapeutic targets or tools for the treatment of asthma and COPD.