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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitisGWAS analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis suggested shared genetic mechanisms across rhinitis-related traits
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Reduced heart rate variability in a treatment-seeking early psychosis sampleFindings provide preliminary evidence that early psychosis is associated with reduced heart rate variability
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Child-parent agreement on alcohol-related parenting: Opportunities for prevention of alcohol-related harmParent non-supply of alcohol and disapproval of use were most important in terms of associations with ever drinking
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Childhood Maltreatment and Early Developmental Vulnerabilities at Age 5 YearsThis study examined associations between maltreatment and early developmental vulnerabilities in a population sample of 68,459 children
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Most clinical anti-EGFR antibodies do not neutralize both wtEGFR and EGFRvIII activation in gliomaWe discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII
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An urgent need for antimicrobial stewardship in Indigenous rural and remote primary health careWe write this perspective to raise awareness of antimicrobial resistance as an issue in Indigenous primary health care
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International experience in the development of patient-derived xenograft models of diffuse intrinsic pontine gliomaThis multi-center study provides valuable information on the success rate of establishing patient-derived pre-clinical models of diffuse intrinsic pontine glioma
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Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of damsWhile maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring
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C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution.We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system
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A Diagnosis for All Rare Genetic Diseases: The Horizon and the Next FrontiersThere is a critical need for the field to develop and implement strategies to understand the mechanisms underlying all rare diseases and translate these to clinical care