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Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial CellsApically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces.
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Assessment of p.Phe508del-CFTR functional restoration in pediatric primary cystic fibrosis airway epithelial cellsThis study assessed an alternative approach, using a small scale halide assay that can be adapted for a personalized high throughput setting to analyze CFTR function of pAEC.
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Current options in aerosolised drug therapy for children receiving respiratory supportIn this review, we explore current knowledge and provide guidance as to when and how the inhaled route may be of value when treating patients whose tracheas are intubated
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Children’s regenerative and genetic medicine programThe project aims to build capacity in regenerative medicine for children with respiratory diseases.
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Compound Repurposing Into Novel Therapeutics In COVID-19 At risk Lungs (CRITICAL Study)Anthony Christopher David Ingrid Shannon Thomas Kicic Blyth Martino Laing Simpson Iosifidis BSc (Hons) PhD MBBS (Hons) DCH FRACP FRCPA PhD BSc PhD
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Epithelial Drivers of Neutrophil Plasticity in Early Cystic Fibrosis Lung DiseaseHallmarks of cystic fibrosis (CF) airway disease include bronchiectasis, airway inflammation by infiltrating polymorphonuclear neutrophils (PMNs) and recurring infection.
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WA Epithelial Research Program for Childhood Respiratory DiseasesOnce thought to be a simple barrier to the external environment, epithelial cells are involved in many repair and inflammatory processes that occur in childhood airway diseases.
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COCOON: Virus transmission, immunity, and family wellbeing during COVID-19The delay in community transmission of the new Coronavirus in WA, together with the strict, social distancing measures that have been adopted, provide us with an opportunity to observe the level of immunity development to the virus within the community and assess the impact of COVID-19 pandemic on health and well-
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Funding boost for cancer, antimicrobial resistance, and pain management treatmentsThe Kids Research Institute Australia researchers will share in $2.3 million awarded by the Western Australian Department of Health Innovation Seed Fund.
Research
Reduced transforming growth factor β1 (TGF-β1) in the repair of airway epithelial cells of children with asthmaEvidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells.