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Comments and Controversies in Oncology: The Tribulations of Trials Developing ONC201Our international team highlights issues with efficacy reports in several studies on DMG with the new drug ONC201.
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IDH mutant high-grade gliomasGliomas are the most common type of malignant primary central nervous system (CNS) tumors, resulting in significant morbidity and mortality in children and adolescent and young adult (AYA) patients. The discovery of mutations in isocitrate dehydrogenase (IDH) genes has dramatically changed the classification and understanding of gliomas. IDH mutant gliomas have distinct clinical, pathological, and molecular features including a favorable prognosis and response to therapy compared to their wildtype counterparts.
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A New Era for PPARγ: Covalent Ligands and Therapeutic ApplicationsPeroxisome proliferator-activated receptor γ (PPARγ) is a prominent ligand-inducible transcription factor involved in adipocyte differentiation, glucose homeostasis, insulin sensitivity, inflammation, and cell proliferation, making it a therapeutic target for diabetes, metabolic syndrome, autoimmune diseases, and cancer.
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“If you build it, they will come”: the convergence of funding, research and collaboration in paediatric brain cancer clinical trialsEach year, approximately 1000 children in Australia and New Zealand, aged 0–14 years, are diagnosed with cancer. Despite paediatric cancer accounting for less than 1% of all cancer cases, the impact on their families and communities is profound and disproportionate.
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Exposure to household painting and floor treatments, and parental occupational paint exposure and risk of childhood brain tumorsThis study investigated whether household exposure to paints and floor treatments and parental occupational painting were associated with CBT risk...
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Maternal Use of Folic Acid and Other Supplements and Risk of Childhood Brain TumorsInterest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers...
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Maternal consumption of coffee and tea during pregnancy and risk of childhood brain tumors: results from an Australian case-control studyThe aim of this analysis was to investigate whether maternal coffee or tea consumption during pregnancy was associated with the risk of CBT.
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Childhood brain tumours: Associations with parental occupational exposure to solventsPaternal exposure to solvents in the year before conception was associated with an increased CBT risk. This increased risk appeared to be mainly attributable...
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Molecular characterization of identical, novel MLL-EPS15 translocation and individual genomicAcute Lymphoblastic Leukemia (ALL) occurring in the first year of life is rare.
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Factors relating to pregnancy and birth and the risk of childhood brain tumors: Results from an Australian case-control studyChildhood brain tumors (CBT) are the leading cause of cancer death in children, yet their causes are largely known. This study investigated the association...