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Pharmacological ablation of the airway smooth muscle layer—Mathematical predictions of functional improvement in asthma

Findings provide further proof of concept that pharmacological targeting of airway smooth muscle thickness will be beneficial and may be facilitated by azithromycin

The Evolving Landscape of e-Cigarettes: A Systematic Review of Recent Evidence

This review focuses on smokers and nonsmokers and evaluates the most recent data regarding the potential health effects of e-cigarettes

Editorial overview: Endocrine and metabolic adaptations to extreme environments: Living life to the extreme – insights into the limits of life and transitions to disease

The need to understand responses to extreme environments has prompted this edition of Current Opinion in Endocrine and Metabolic Research

Intrauterine growth restriction affects diaphragm function in adult female and male mice

Sex and intrauterine growth restriction independently affect diaphragm contraction in adult mice without changes in structure

Early-life exposure to electronic cigarettes: cause for concern

There are a multitude of ways that, with respect to early-life exposures and health, electronic nicotine delivery systems are a cause for concern

Soy Biodiesel Exhaust is More Toxic than Mineral Diesel Exhaust in Primary Human Airway Epithelial Cells

Exposure to biodiesel exhaust resulted in significantly greater cell death and a greater release of immune mediators compared to both air controls and ULSD exhaust

Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams

While maternal high fat diet compromised litter survival, it also promoted somatic and lung growth (increased lung volume) in the offspring

Transplacental immune modulation with a bacterial-derived agent protects against allergic airway inflammation

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention

The Use of Alcohol Pharmacotherapies and Prescription Contraceptives among Females of Reproductive Age in Australia

There is no clear clinical guidance on the use of alcohol pharmacotherapies in pregnancy due to insufficient safety information. Contraception should therefore be considered for reproductive-aged females receiving alcohol pharmacotherapies not wishing to become pregnant. This study evaluated the concurrent use of alcohol pharmacotherapies with prescription contraception and other medications in Australian females of reproductive age compared to those not receiving an alcohol pharmacotherapy.

Prenatal Origins of Obstructive Airway Disease: Starting on the Wrong Trajectory?

From the results of well-performed population health studies, we now have excellent data demonstrating that deficits in adult lung function may be present early in life, possibly as a result of developmental disorders, incurring a lifelong risk of obstructive airway diseases such as asthma and chronic obstructive pulmonary disease.