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Research

Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden.

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Cellular and molecular mechanisms of vitamin D in food allergy

Epidemiological evidence from the past decade suggests a role of vitamin D in food allergy pathogenesis

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Analytical bias in the measurement of serum 25-hydroxyVitamin D concentrations impairs assessment of Vitamin D status

This publication demonstrated considerable differences in the measurement of 25-hydroxyvitamin D concentrations compared with a certified laboratory, even...

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Vitamin D deficiency at melanoma diagnosis is associated with higher Breslow thickness

Background: Epidemiological evidence shows that people with thicker, or higher stage, melanomas have lower vitamin D status compared to those with thinner...

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Heat-mediated reduction of apoptosis in UVB-damaged keratinocytes in vitro and in human skin ex vivo

UVB-induced p53-mediated cell cycle arrest and apoptosis are reduced in the presence of heat stress, leading to increased survival of DNA damaged cells

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Serum 25-hydroxyvitamin D concentrations and cardiometabolic risk factors in adolescents and young adults

Associations between serum 25(OH)D concentrations and cardiometabolic risk factors from adolescence to young adulthood in the Raine Study

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Nutritional approaches for the primary prevention of allergic disease: An update

The dramatic rise in early childhood allergic diseases indicates the specific vulnerability of the immune system to early life environmental changes.

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Incidence of nonmelanoma skin cancer in relation to ambient UV radiation in white populations, 1978-2012 empirical relationships

This paper examined dose-response relationships between ambient UVR levels and NMSC incidence at the population level.

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Novel drug targets for asthma and COPD: Lessons learned from in vitro and in vivo models

This paper is a review of potential novel therapeutic targets or tools for the treatment of asthma and COPD.

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What is the optimal level of vitamin D?: Separating the evidence from the rhetoric

New evidence indicates that both high and low 25(OH)D levels may be associated with increased health risks.