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Bile acid signalling is a leading trigger for the development of chronic phenotypes underlying the pathophysiology of chronic respiratory disease
First trimester maternal levels of serum free-beta hCG are not associated with hypospadias or undescended testis
Maternal n-3 LCPUFA supplementation did not provide sustained effects on postnatal oxidative stress and telomere length as observed in the offspring
Identified dominant PCR-ribotypes common to geographically disparate Australian paediatric populations
Understanding early triggers of Cystic Fibrosis Lung Disease
Reported practice of some professionals in Australia may not be consistent with international best practice guidelines for ASD diagnosis
How different somatosensory modalities develop across childhood into adolescence to use as a point of reference for children at risk of somatosensory
The RACP is advancing a three-tier strategy to build greater specialist capacity and sustain leadership in adolescent and young adult medicine
For hospital-based clinicians wishing to establish AYA services, how should they proceed and what might such services look like?
The proportion of children and adolescents in Australia with mental disorders who used services for emotional and behavioural problems
In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.
Respiratory viruses significantly impact global morbidity and mortality, causing more disease in humans than any other infectious agent. Beyond pathogens, various viruses and bacteria colonize the respiratory tract without causing disease, potentially influencing respiratory diseases’ pathogenesis.
Functional studies of how early-life interventions shape the airway microbiome remain scarce. Here, we performed metagenomic sequencing of 704 longitudinal nasal swabs from infants with and without cystic fibrosis (CF) to construct and characterize a non-redundant gene atlas of the infant nasal microbiome. We aimed to determine how the nasal microbiome is perturbed by early therapies, as CF is commonly treated with inhaled hypertonic saline to improve mucociliary clearance.
For decades, cystic fibrosis (CF) meant a life shaped by daily treatments, frequent hospitalisations, and an uncertain future. The arrival of CFTR modulators has changed that picture dramatically, and researchers at the Wal-yan Respiratory Research Centre now want to understand the bigger picture.
Scientists at The Kids Research Institute Australia are taking their fight against antibiotic- resistant superbugs to the Goldfields working alongside local Indigenous communities and councils.
Respiratory disease is a leading cause of hospitalisations in children with cerebral palsy (CP). Over 40% of individuals with CP are born preterm; however, the relationship between prematurity, CP and respiratory disease is unknown.