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Paediatric Active Enhanced Diseases Surveillance (PAEDS)

PAEDS monitors for key vaccine preventable conditions and severe side effects from vaccine in 5 paediatric hospitals in Australia.

Investigators: Dr Christopher Blyth

External collaborators: Kristine Macartney, Nicholas Wood, Peter McIntyre, Elizabeth Elliott, Robert Booy, Philip Britton, Jim Buttery, Nigel Crawford, Peter Richmond, Helen Marshall, Julia Clark, Anne Kynaston, Joshua Francis, Brendan McMullan

Partners: Marie Bashir Institute, National Health and Medical Research Council, WA Department of Health

PAEDS commenced as a pilot project in 2007, under the leadership of the National Centre for Immunisation Research and Surveillance and the Australian Paediatric Surveillance Unit (APSU) and over the years has continued to grow across Australia. Over this time, surveillance of a number of important paediatric conditions has been included, particularly related to vaccine preventable diseases and adverse events following immunisation. We have a number of publications and have contributed to shaping policy and practice. 7 sites particpate in the PAEDS network:

  • The Childrens Hospital at Westmead, Sydney
  • The Royal Children’s Hospital, Melbourne
  • Monash Health, Melbourne
  • Queensland Children’s Hospital, Brisbane
  • Women’s and Children Hospital, Adelaide
  • Perth Children's Hospital, Perth
  • Royal Darwin Hospital, Darwin
  • The Sydney Childrens Hospital Randwick, Sydney

PAEDS continues to conduct surveillance for twelve main conditions, which are either vaccine preventable diseases, potential adverse events following immunisation or other important conditions of importance from a public and child health perspective. These conditions are:

  1. Acute flaccid paralysis (AFP)
  2. Intussusception (ISS)
  3. Varicella/herpes zoster (from varicella zoster virus, VZV)
  4. Pertussis (PSS)
  5. Acute childhood encephalitis (ACE)
  6. Influenza (FluCAN – Influenza Complications Alert Network)
  7. Invasive Meningococcal Disease (IMD)
  8. Kawaski Disease (KD)
  9. Gram-negative blood stream infection (GNBSI)
  10. COVID-19 (SARS-CoV-2)
  11. Paediatric Inflammatory Multisystem Syndrome temporally associated with SARS-CoV-2 (PIMS-TS )

Funders: Commonwealth Department of Health, WA Department of Health.