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Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors

CD8+ T cells are an important weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognoses, the tumor microenvironment also contains dysfunctional exhausted T (TEX) cells that exhibit a variety of TRM-like features.

Citation:
Burn TN, Schroeder J, Gandolfo LC, …….. Waithman J, Gebhardt T, et al. Antigen reactivity defines tissue-resident memory and exhausted T cells in tumors. Nat Immunol. 2026;27(1):98-109.

Keywords:
Immunology; lymphocytes; memory T-cells' neoplasms; tumor microenvironment; CD8-positibe T-lymphocytes

Abstract:
CD8+ T cells are an important weapon in the therapeutic armamentarium against cancer. While CD8+CD103+ T cells with a tissue-resident memory T (TRM) cell phenotype are associated with favorable prognoses, the tumor microenvironment also contains dysfunctional exhausted T (TEX) cells that exhibit a variety of TRM-like features.