Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life

Dynamic cellular and molecular adaptations in early life significantly impact health and disease. Upon birth, newborns are immediately challenged by their environment, placing urgent demands on the infant immune system.

Citation:
Kouyate TS, Nguyen AN, Plotkin AL, ……. Kollmann TR, Richmond PC, van den Biggelaar AHJ, Kampmann B, et al. Plasma adenosine deaminase-1 and -2 activities are lower at birth in Papua New Guinea than in The Gambia but converge over the first weeks of life. Front Immunol. 2024;15.

Keywords:
Adenosine deaminase; global health; immune development; infant; ontogeny

Abstract:
Dynamic cellular and molecular adaptations in early life significantly impact health and disease. Upon birth, newborns are immediately challenged by their environment, placing urgent demands on the infant immune system.