Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies

Reasons for Th2 skewing in IgE-mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4+ T cells in children with IgE-mediated food allergies.

Citation:
Lai CL, Santner-Nanan B, Maltese PJ, ……. Palmer DJ, Campbell DE, ……. Prescott SL, Hsu PS. Impaired calcium influx underlies skewed T helper cell differentiation in children with IgE-mediated food allergies. Allergy Eur J Allergy Clin Immunol. 2024.

Keywords:
IgE‐mediated food allergy; helper T cells; naïve CD4 T cells; regulatory T cell; store operated calcium entry (SOCE)

Abstract:
Reasons for Th2 skewing in IgE-mediated food allergies remains unclear. Clinical observations suggest impaired T cell activation may drive Th2 responses evidenced by increased atopic manifestations in liver transplant patients on tacrolimus (a calcineurin inhibitor). We aimed to assess differentiation potential, T cell activation and calcium influx of naïve CD4+ T cells in children with IgE-mediated food allergies.