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Childhood leukaemia in Down's syndrome primed by blood-cell bias

An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.

Citation:
Malinge S. Childhood leukaemia in Down's syndrome primed by blood-cell bias. Nature. 2024;634(8032):40-2 

Keywords:
Blood Cells/pathology ; Down syndrome; Leukemia; Cancer; Diseases; Epigenetics; Transcriptomics

Abstract:
An in-depth investigation of gene regulation and cell populations at sites of fetal blood-cell production provides clues as to why children with Down’s syndrome are predisposed to developing leukaemia.