Keywords:
Brief limited intermittent psychotic symptoms; disorganized speech; negative symptoms; prediction model calibration; prediction of transition to psychosis; psychosocial functioning; temporal validation; UHR 1000+ cohort; Ultra-high risk for psychosis; unusual thought content
Abstract:
The concept of ultra-high risk for psychosis (UHR) has been at the forefront of psychiatric research for several decades, with the ultimate goal of preventing the onset of psychotic disorder in high-risk individuals. Orygen (Melbourne, Australia) has led a range of observational and intervention studies in this clinical population.