A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait

Grip strength is a proxy measure for muscular strength and a predictor for bone fracture risk among other diseases. Previous genome-wide association studies have been conducted in large cohorts of adults focusing on scores collected for the dominant hand, therefore increasing the likelihood of confounding effects by environmental factors.

Citation:
Abbondanza F, Wang CA, Schmitz J, ....... Whitehouse AJO, Paracchini S. A GWAS for grip strength in cohorts of children-Advantages of analysing young participants for this trait. Genes Brain Behav. 2024;23(5):e70003.

Keywords:
ALSPAC; GWAS; Raine study; complex traits; grip strength; neurodevelopment

Abstract:
Grip strength is a proxy measure for muscular strength and a predictor for bone fracture risk among other diseases. Previous genome-wide association studies have been conducted in large cohorts of adults focusing on scores collected for the dominant hand, therefore increasing the likelihood of confounding effects by environmental factors.