Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening – A nationwide observational study

Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.

Citation:
Frauchiger BS, Willers C, Cotting J, …….. Ramsey KA. Lung structural and functional impairments in young children with cystic fibrosis diagnosed following newborn screening – A nationwide observational study. J Cyst Fibrosis. 2024.

Keywords:
Children; Cystic fibrosis; Lung clearance index; Magnetic resonance imaging; Multiple breath washout

Abstract:
Non-invasive and sensitive clinical endpoints are needed to monitor onset and progression of early lung disease in children with cystic fibrosis (CF). We compared lung clearance index (LCI), FEV1, functional and structural lung magnetic resonance imaging (MRI) outcomes in Swiss children with CF diagnosed following newborn screening.