A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes

Autoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates.

Citation:
Harrison LC, Bandala-Sanchez E, Oakey H, ……. Haynes A, Thomson RL, Vuillermin PJ, ……. Davis EA, Hamilton-Williams E, Harris M, ……. Tully A, Vicary I, Wood R, ……. Binkowski S, Brittain B, Bui M, et al as part of the ENDIA Study Group. A surge in serum mucosal cytokines associated with seroconversion in children at risk for type 1 diabetes. J Diabetes Invest. 2023

Keywords:
Islet autoantibody; Seroconversion; Serum cytokine

Abstract:
Autoantibodies to pancreatic islet antigens identify young children at high risk of type 1 diabetes. On a background of genetic susceptibility, islet autoimmunity is thought to be driven by environmental factors, of which enteric viruses are prime candidates.