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Unstable SpO2 in preterm infants: The key role of reduced ventilation to perfusion ratio

Instability of peripheral oxyhemoglobin saturation (SpO2) in preterm infants is correlated with late disability and is poorly understood. We hypothesised that a reduced ventilation to perfusion ratio (VA/Q) is the key predisposing factor for SpO2 instability.

Citation:
Stoecklin B, Choi YJ, Dassios T, Jones JG, Lockwood GG, Pillow JJ. Unstable SpO2 in preterm infants: The key role of reduced ventilation to perfusion ratio. Front Physiol. 2023;14

Keywords:
Infant; neonatal intensive care unit; oxygen inhalation therapy; premature; pulmonary gas exchange

Abstract:
Instability of peripheral oxyhemoglobin saturation (SpO2) in preterm infants is correlated with late disability and is poorly understood. We hypothesised that a reduced ventilation to perfusion ratio (VA/Q) is the key predisposing factor for SpO2 instability.