Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents

Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described.

Citation:
Imran S, Neeland MR, Martino DJ, Peng S, Koplin J, …….. Prescott S, Perrett KP, et al. Epigenomic variability is associated with age-specific naïve CD4 T cell response to activation in infants and adolescents. Immunol Cell Biol. 2023

Keywords:
DNA methylation; adaptive immunity; adolescents; aging; infants; nCD4 T cells

Abstract:
Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described.