Population pharmacokinetic study of benzathine penicillin G administration in Indigenous children and young adults with rheumatic heart disease in the Northern Territory, Australia

Citation:
Kado J, Salman S, Hand R, O'Brien M, Ralph A, Bowen AC, Page-Sharp M, ……. Carapetis J, Manning L. Population pharmacokinetic study of benzathine penicillin G administration in Indigenous children and young adults with rheumatic heart disease in the Northern Territory, Australia. J Antimicrob Chemother. 2022;77(10):2679-82.

Keywords:
Antiinfective agent; benzathine penicillin; liquid chromatography;
Northern Territory; rheumatic fever; rheumatic heart disease; Streptococcus pyogenes; tandem mass spectrometry; Anti-Bacterial Agents

Abstract:
Benzathine penicillin G is the cornerstone of secondary prophylaxis to prevent Streptococcus pyogenes infections, which precede acute rheumatic fever.