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Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth

Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM.

Citation:
Savigni DL, Chang AY, Sorensen NL, Papagianis PC, Ahmadi-Noorbakhsh S, Pillow JJ, Noble PB. Airway smooth muscle thickness and contraction are enhanced by intra-amniotic lipopolysaccharide in an ovine model of premature birth. J Appl Physiol (1985). 2022;133(4):959-69.

Keywords:
Asthma; bronchoconstriction; chorioamnionitis; inflammation; acetylcholine;
muscle contraction; pregnancy; pregnancy complication; prematurity; smooth muscle

Abstract:
Abnormalities of the airway smooth muscle (ASM) layer in asthma may develop before birth. We hypothesize that antenatal inflammation causes physiological abnormalities of the ASM that predisposes asthma. This study determined the short-term effects of antenatal inflammation on the developing ASM.