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Antifungal use in children with acute leukaemia: state of current evidence and directions for future research

Invasive fungal disease (IFD) remains a common and serious complication in children treated for leukaemia. Antifungal prescription in children with leukaemia presents unique challenges, particularly due to variation in IFD risk between and within leukaemia treatment protocols, drug toxicities and interactions between antifungals and chemotherapeutic agents.

Citation:
Yeoh DK, Haeusler GM, McMullan BJ, …….. Kotecha RS, Lai T, Slavin MA, Thursky KA, Blyth CC. Antifungal use in children with acute leukaemia: state of current evidence and directions for future research. J Antimicrob Chemother. 2022;77(6):1508-24.

Keywords:
Antifungal agent; acute myeloid leukemia; hematology; mycology; systemic mycosis; Antifungal Agents; Invasive Fungal Infections; Leukemia, Myeloid, Acute

Abstract:
Invasive fungal disease (IFD) remains a common and serious complication in children treated for leukaemia. Antifungal prescription in children with leukaemia presents unique challenges, particularly due to variation in IFD risk between and within leukaemia treatment protocols, drug toxicities and interactions between antifungals and chemotherapeutic agents.