Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis

Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebello-thalamo-cortical structures, but it is unclear whether similar structures underlie NSS prior to the onset of psychosis. The present study investigated the relationship between severity of NSS and grey matter volume in individuals at ultra-high risk for psychosis stratified for later conversion to psychosis.

Citation:
Wang Y, Braam EE, Wannan CMJ, Van Rheenen TE, Lin A, Brewer WJ, et al. Investigation of structural brain correlates of neurological soft signs in individuals at ultra-high risk for psychosis. Eur Arch Psychiatry Clin Neurosci. 2021;271(8):1475-85.

Keywords:
Grey matter volume; Neurological soft signs; Transition; Ultra-high risk; Voxel-based morphometry

Abstract:
Increased severity of neurological soft signs (NSS) in schizophrenia have been associated with abnormal brain morphology in cerebello-thalamo-cortical structures, but it is unclear whether similar structures underlie NSS prior to the onset of psychosis. The present study investigated the relationship between severity of NSS and grey matter volume in individuals at ultra-high risk for psychosis stratified for later conversion to psychosis.