Authors:
Ayonrinde OT, Adams LA, Doherty DA, Mori TA, Beilin LJ, Oddy WH, et al.
Authors notes:
Journal of Gastroenterology and Hepatology (Australia). 2016;31(5):980-7.
Keywords:
C-reactive protein, Community, Insulin resistance, Non-alcoholic fatty, liver disease, Obesity, Polycystic ovary syndrome, Raine study, Testosterone
Abstract:
Background and Aims: Non-alcoholic fatty liver disease (NAFLD) and polycystic ovary syndrome (PCOS) share risk associations of adiposity and insulin resistance.
We examined the impact of a PCOS diagnosis on the metabolic phenotype of adolescent girls with NAFLD and compared this to girls without PCOS or NAFLD and to age-matched boys.
Methods: Community-based adolescents from the Raine Cohort participated in assessments for NAFLD (572 girls and 592 boys) and PCOS (244 girls).
One hundred and ninety-nine girls attended both assessments.
Results: Amongst the 199 girls, PCOS was diagnosed in 16% and NAFLD in 19%.
NAFLD was diagnosed in 10% of the boys.
NAFLD was more prevalent in girls with PCOS than girls without PCOS (38% vs 15%).
Girls with NAFLD plus PCOS had greater adiposity (waist circumference, body mass index, suprailiac skinfold thickness [SST], serum androgens, high-sensitivity C-reactive protein, ferritin, homeostasis model assessment for insulin resistance (HOMA-IR), and lower serum sex hormone binding globulin levels than girls with NAFLD without a PCOS diagnosis.
Girls with NAFLD plus PCOS had similar adiposity, HOMA-IR, and adiponectin levels to boys with NAFLD, but more adiposity, serum leptin and HOMA-IR than both girls and boys without NAFLD.
PCOS and SST independently predicted NAFLD in adolescent girls, however, serum androgens and HOMA-IR levels did not.
Conclusions: Adolescent girls with NAFLD plus PCOS have a similar metabolic phenotype to boys with NAFLD.
Increasing SST and pre-existing PCOS independently predict NAFLD in adolescent girls.