Authors:
Woodward EA, Prêle CM, Nicholson SE, Kolesnik TB, Hart PH.
Authors notes:
Immunology. 2010 Sep;131(1):118-27. Epub 2010 Apr 6.
Keywords:
anti-inflammatory effects, interleukin-4, mediated by suppressor of cytokine signalling-1 (SOCS1)
Abstract:
While it is known that the anti-inflammatory effects of interleukin (IL)-4 require new protein synthesis, the exact mechanisms by which IL-4 suppresses the production of pro-inflammatory cytokines by human monocytes and macrophages is unclear. IL-4 rapidly induced suppressor of cytokine signalling-1 (SOCS1) mRNA and protein, which peaked at 60 min, much earlier than lipopolysaccharide (LPS)-induced SOCS1 mRNA and protein which were consistently maximal 4 hr post-exposure.