Glucocorticoid resistance in T-lineage acute lymphoblastic leukaemia is associated with a proliferative metabolism

We examined the baseline profile of a panel of T-ALL cell lines to determine factors that contribute to GC resistance without prior drug selection.

Authors:
Beesley AH, Fir th MJ, Ford J, Weller RE, Freitas JR, Perera KU, Kees UR

Authors notes:
British Journal of Cancer. 2009 Jun 16;100(12):1926-36. Epub 2009 May 12

Keywords:
Glucocorticoid resistance, T-lineage acute lymphoblastic leukaemia, proliferative metabolism

Abstract:
Glucocorticoids (GCs) are among the most important drugs for acute lymphoblastic leukaemia (ALL), yet despite their clinical importance, the exact mechanisms involved in GC cytotoxicity and the development of resistance remain uncertain. We examined the baseline profile of a panel of T-ALL cell lines to determine factors that contribute to GC resistance without prior drug selection.