Melinda Judge, Erica Parker, Denise Naniche, Lucia Pastor, Kim W Carter, Denise Anderson, Peter LeSouëf.
This is the largest acute HIV cohort recruited in sub-Saharan Africa, the first study to use the RNA-seq platform to investigate gene expression during early HIV infection and, importantly, the first to consider HIV-1 subtype C which is responsible for more than half of infections globally.
Plain Language summary: The ability to accurately identify acute HIV infection (AHI) in a resource-limited setting would enable earlier and optimised treatments for individual patients, and also contribute to reducing onward transmission. Identification of reliable biomarkers for use in novel incidence assays is required. This study investigated host gene expression in response to new HIV infection.
Funder: Bill and Melinda Gates Foundation
External collaborators:
- Denise Naniche, ISGlobal, Barcelona, Spain
- Lucia Pastor, IrsiCaixa Institute for AIDS Research, Institut Germans Trias i Pujol (IGTP), Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, UAB, Badalona, Spain